Advalytix’s polar body pre-implantation genetic diagnostics (PGD) kit is built upon the single cell sensitivity of the AmpliGrid slide, the multiplex assay design acumen of Advalytix’s multiplex assay design service, and the gene-counting ability of Advalytix’s digital counting intellectual property.

The kit, along with the AmpliSpeed cycler, and standard molecular detection instrumentation allows IVF practices to conduct PGD analysis in-house.  IVF practitioners who do not wish to build the necessary molecular diagnostics infrastructure  can send their samples to Advalytix’s Munich headquarters for processing (full service offer).

PGD is used in conjunction with in-vitro-fertilization (IVF).  The Advalytix kit detects presence or absence of all chromosomes from polar-bodies.  If all chromosomes are present on a polar body, the corresponding oocyte is likely free of aneuploidies (chromosome disorders) and any embryo generated from that fertilized oocyte is free from aneuploidies as well (very few embryonic aneuploidies stem from the sperm).  By giving the IVF physician the ability to select embryos for implantation that are likely free of aneuploidies, PGD may boost boost IVF’S implantation success rate.
The key advantage of Advalytix’s PGD vs. FISH (fluorescence in-situ hybridization)-based PGD is that it screens all chromosomes, while FISH screens only 5-12 chromosomes.  In addition, the results of the Advalytix kit are digital in nature, eliminating the subjectivity of results interpretation associated with FISH.